| Product | Amount of factor contained |
|---|---|
| Cryoprecipitate | Each bag contains ~100 units of factor |
| FFP | 1 unit/mL (one unit of factor per mL of plasma) |
| Whole blood | 1 unit/mL (one unit of factor per mL of whole blood) |
| Types of Hemorrhage | Examples | Desired Factor Level | Factor VIII Dose | Factor IX Dose |
|---|---|---|---|---|
| Minor | Lacerations Mild Hemarthrosis Hematomas |
30 – 50 % | 12.5 units/kg | 25 units/kg |
| Moderate | Dental Procedures Epistaxis Hematuria |
50 - 75 % | 25 units/kg | 50 units/kg |
| Severe | CNS Retroperitoneal Retropharyngeal Severe GI Major Surgery |
75 – 100 % | 50 units/kg | 100 units/kg |
Note: dosing for factor IX is double that of factor VIII.
Patients with mild hemophilia A may respond to treatment with desmopressin (DDAVP) at 0.3 mcg/kg IV every 12 hours. The mechanism through which DDAVP works is not entirely understood but likely acts through increasing von Willebrand factor. DDAVP can raise factor VIII activity level (not amount) threefold within one hour of administration.